The chief executive of one of the country’s largest NHS trusts is to quit his post to take up a role in Singapore.

Steve Smith is standing down from his post at Imperial College Healthcare Trust to join Nanyang Technological University in Singapore.

Professor Smith is the founding dean of the Lee Kong Chian School of Medicine in Singapore, a joint venture between Imperial College London and Nanyang Technological University.

His resignation takes effect from 20 September and a replacement has not been found.

Professor Smith created one of the UK’s first academic health science centres in 2009 when the trust formed a partnership with Imperial College London.

Imperial College Healthcare Trust, which had a £900m income in 2009-10, was formed on 1 October 2007 when it merged with Hammersmith Hospitals Trust and St Mary’s Trust, becoming one of the largest trusts in the NHS.

The majority of its services are commissioned by the North West London cluster which comprises Brent, Ealing, Hammersmith and Fulham, Harrow, Hillingdon, Hounslow, Kensington and Chelsea and Westminster PCTs.