Andrew Lansley will tomorrow announce two hospitals that will offer Proton Beam Therapy for the treatment of cancer.
The £266m capital project will see the technology deployed at University College London Hospitals Foundation Trust and The Christie Foundation Trust in Manchester.
Proton Beam Therapy is a form of radiotherapy that is often useful in treating child cancer cases as well as brain, head and neck cancer.
There is currently no service offering the therapy in the UK and patients have to travel abroad.
The DH will fund the scheme and estimates the annual revenue spend on proton beam therapy will be £37m, with the first patients being treated in London by February 2018 and in Manchester by November 2017.
The decision indicates the department has decided on a two-centre configuration rather than an alternative three-site plan that would have seen the facilities also provided at University Hospitals Birmingham Foundation Trust.