Mike O’Brien and Gillian Merron have been named as new ministers at the Department of Health.
They replace Ben Bradshaw and Dawn Primarolo, but the new ministers’ portfolios are yet to be confirmed.
The government has also confirmed Phil Hope will continue as a minister at the department following the reshuffle.
Mr O’Brien was previously a minister at the Department for Energy and Climate Change, and Ms Merron a parliamentary under-secretary of state at the Foreign and Commonwealth Office.
The announcement follows the replacement of health secretary Alan Johnson by Andy Burnham.