The new organisation, run by the NHS Alliance, says it hopes to bring together primary care trusts and practices to achieve major changes.
The chief executive transformation network, known as CETNet, is already planning to produce a publication describing the elements that are needed to drive changes through practice-based commissioning.
Tameside and Glossop PCT chief executive Tim Riley will be the national lead for CETNet, supported by NHS Alliance director Julie Wood.
Mr Riley said it was crucial for PCT chief executives and clinicians to come together to achieve a lasting and patient-centred transformation of the NHS's services.
He added: 'PCTs are uniquely placed to re-connect with primary care clinicians and local communities.
'It is critical that we do this well. This is what CETNet will be focusing on.'
NHS Alliance chair Dr Michael Dixon said CETNet would build on the alliance's work: 'I am confident that CETNet will show the NHS the best way forward for the future.'