Blackpool, Fylde and Wyre Hospitals foundation trust chief executive Julian Hartley is to run University Hospital of South Manchester foundation trust for two and a half months.
Previous South Manchester chief executive Peter Morris was appointed interim chief executive at Barts and the London trust following the departure of Julian Nettel.
Blackpool deputy chief executive Aidan Kehoe will act as chief executive from 30 March to 19 June, while Mr Hartley is on secondment.
South Manchester chair Felicity Goodey said: "On behalf of the staff and board of UHSM, we warmly welcome Julian and I am very grateful to the chair and board of Blackpool for agreeing to lend him to us."
Blackpool chair Beverly Lester added: "It is flattering that we have been approached by UHSM due to our growing reputation as a successful and effective foundation trust which has a strong team of executive directors.
"South Manchester is recognised as a centre of clinical excellence with a reputation for providing high quality teaching and research.
"This is an excellent opportunity for Julian to experience the management of a major teaching hospital and we feel that this secondment will be of mutual benefit."
Julian Nettel left Barts suddenly at the beginning of last month.
It has not been given a date to become a foundation trust, largely because of concerns that its£1bn hospital private finance initiative will be unaffordable.