The Healthcare Commission is to investigate concerns about care and management at Birmingham Children's Hospital foundation trust.
Clinicians at the hospital and at University Hospital Birmingham foundation trust complained of "poor and disorganised management processes and lack of confidence in managers at all levels". They also described failure to report clinical incidents, a feeling their concerns about care had not been taken seriously and staffing problems.
The trust's commissioning primary care trusts, led by Heart of Birmingham teaching PCT, ordered it to carry out a review.
Heart of Birmingham chief executive Sandy Bradbrook said: "This is a good example of how commissioning organisations can exert appropriate pressure and direction [to] ensure patient safety and improvement of quality services."
A spokesperson for the hospital said: "The issues [are] all standard operational ones and we have agreed a plan with the PCTs and the clinicians concerned." It has asked Great Ormond Street Hospital to review the situation.
The Healthcare Commission said it would investigate at the request of health secretary Alan Johnson.