Mr Lansley said resource allocation needs to be reviewed and public health money should be separately allocated to avoid it being swallowed up by other priorities.
His comments followed.junior health minister Professor Sir Ara Darzi's NHS London report, which said there were fewer GPs where need is greatest.
The report also said if primary care trusts in spearhead areas met the target to bring life expectancy up to the national average, it would diminish one of the major health inequalities in the capital.
An NHS London spokesperson said: 'We accept investment, including the spread of GPs, is not concentrated where the need is greatest.
'Sir Ara's report contains many recommendations which could help tackle inequalities.
'Raising life expectancy for the bottom half of London's boroughs to the capital's average alone would save around 1,300 lives a year.'
Association of Directors of Public Health president Dr Tim Crayford said incentives to draw GPs into deprived areas had not been enough.