Initial plans are being drawn up by the National Patient Safety Agency, the NHS Institute for Innovation and Improvement and the Health Foundation.
There was also 'enthusiastic discussion' of the campaign at the third meeting of the National Patient Safety Forum last week, co-chaired by NHS chief executive David Nicholson and chief medical officer Sir Liam Donaldson.
Health Foundation chief executive Stephen Thornton said there had been an acceptance at the meeting that a national campaign would be a 'major task', but it was a positive conversation.
NPSA chief executive Martin Fletcher said it was leading on the design of a national patient safety campaign initiative, as recommended by Safety First - a report commissioned by Sir Liam in December to reconsider arrangements in place to ensure that patient safety is at the heart of the healthcare agenda.
Mr Fletcher said: 'This work will prioritise the safety of patients by inspiring people to change behaviour and culture and implement best practice, with many different parts of the NHS collaborating on lessons from successful initiatives.'
Mr Fletcher and Sir Liam also took part in an HSJ and Microsoft roundtable debate published this week. Participants were keen to follow the example of the high profile US Institute for Healthcare Improvement '100,000 Lives' campaign, which raises awareness and aggressively targets patient safety issues.