on the evidence: Diabetes

Intervention Mode of action Comment

Total contact casting A plaster cast which One small randomised controlledredistributes weight on the foot trial showed benefit.

Growth factors Substances derived from Five randomised controlled trials (CT-102, RGDpm, rhPDGF) human tissue which can found they helped uninfected stimulate growth ulcers heal faster. No UK marketing.

Granulocyte-colony stimulating Enhances ability to fight G-CSF reduced infection and factor (G-CSF) infection enhanced healing of severely infected diabetic foot ulcers in one small randomised controlled trial. Not licensed for this indication.2 per cent ketanserin ointment Believed to improve local Two randomised controlled trials blood supply suggested benefit. No UK marketing authorisation.