Health minister Ann Keen has lost her Brentford and Isleworth seat to the Conservatives.
Her defeat means the whole of the Labour health team, apart from health secretary Andy Burnham, has been ousted.
Her Conservative opponent, Mary Macleod, polled almost 2,000 more votes. Ms Macleod said voters cast their ballots for a “change to the way we do politics”.
Health minister Mike O’Brien lost at Warwickshire North to Conservative candidate Dan Byles, who secured a majority of just 54.
Care services minister Phil Hope lost to Tory Louise Bagshawe, who won with 22,886 votes compared with Mr Hope’s 20,935.
Public health minister Gillian Merron received 16,105 votes, but it was not enough to beat Tory Karl McCartney who won 17,163.
Health secretary Andy Burnham held his Leigh seat with 24,295 votes to the Conservatives’ 9,284.
HSJ Post-Election Briefing - Monday 10th May 2010
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Health minister Ann Keen loses seat to Conservatives